Pharmaceutical DPI formulation mixer to mix DPI powder homogeneously
In this article on DPI formulation mixer selection, we would like to highlight some of the considerations that go into developing and processing dry powder inhaler (DPI) formulations.
Oral inhalation is well recognized as an efficient method of drug delivery by major pharmaceutical companies, driving the continuing development of branded as well as generic dry powder inhalers (DPIs). However, the complexities of developing a DPI-suitable formulation require a master stroke: there are several often contradictory requirements these formulations must conform to.
As a case study we can say that in order for the active pharmaceutical ingredient (API) to reach and be absorbed within the lung, the particle size of the API needs to be within the range of 1–5 μm. Individual material characteristics aside, any powder consisting of fine particles is very cohesive by nature and therefore needs to be mixed or blended with a carrier, most frequently lactose, in order to facilitate effective handling and mixing.
Alphie 3D Three Dimensional Mixer can efficiently solve this powder mixing problem.
Typically, a DPI formulation consists of a mixture of one or more APIs blended with, in most cases, two grades of lactose. In order to select the DPI powder mixer, typically homogeneous mixing is recommended for the blending of free-flowing powders. However, for cohesive powders, a 3D (Tri Orbital) mixing technology is advisable. The key to success is applying the correct balance of mixing energy to the formulation in order to break the cohesive forces of the fine API to produce an even distribution across the formulation mixture.
Generally, the results from the conventional mixture methods (Mixed by V-cone, Double Cone, Ribbon, Drum, etc.) are less convincing in stability of homogeneity. For this reason, many industries are diversifying their processes instead of getting a homogeneous powder mixer. It is recommended that this homogeneous mixing issue be attended to instead of trying process diversification. The homogeneous mixing dynamics of DPI Formulation have been proven in Alphie 3D (Tri Orbital) Mixer and Alphie is becoming a known brand for various applications such industries as homogeneous DPI powder mixing. The Alphie 3D powder mixer has been conceived based on the splitting and recombining mechanism, along with a simple topology structure.
Thus, if you are keen to achieve your goals in DPI formulation industry our expert recommendation would be to go with Alphie 3D DPI mixer to get the best homogeneous mixing.
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